SKU: WP14578 Categories: ,

SREC-II Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14578-100
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Product details

Background:

The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetSREC-II
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human SCARF2. AA range:677-726
SpecificitySREC-II Polyclonal Antibody detects endogenous levels of SREC-II protein.
Gene NameSCARF2
Protein NameScavenger receptor class F member 2
Other NameSCARF2; / SREC2; / SREPCR; / Scavenger receptor class F member 2; / SRECRP-1; / Scavenger receptor expressed by endothelial cells 2 protein; / SREC-II
SpeciesHuman
Gene ID91179
UniprotQ96GP6,
Species.1Mouse
Gene ID.1
Uniprot.1P59222
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein .
Tissue ExpressionPredominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary.
Signaling_pathway
Research Areas
FunctionFunction:Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL).,similarity:Contains 7 EGF-like domains.,subunit:Homophilic and heterophilic interaction via its extracellular domain. Interacts with SCARF1. The heterophilic interaction with SCARF1, which is stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand such as Ac-LDL.,tissue specificity:Predominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary.,
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