Name: U-Blot® RIP3 Rabbit mAb
SKU: WR5142
Price: 268 USD
Availability: InStock

U-Blot® RIP3 Rabbit mAb

Ucallm_WR5142-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5142-50

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Product details

Background:The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	RIP3
Reactivity	Human
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	57kD
MW(Observed)	57kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1371R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RIPK3 RIP3
Protein Name	Receptor-interacting serine/threonine-protein kinase 3 (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Other Name	Receptor-interacting serine/threonine-protein kinase 3; / RIP-like protein kinase 3; / Receptor-interacting protein 3; / RIP-3
Species	Human
Gene ID	11035
Uniprot	Q9Y572,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9QZL0,
Species.2	Rat
Gene ID.2	246240
Uniprot.2	Q9Z2P5
Cellular Localization	Cytoplasm, cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
Tissue Expression	Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney.; [Isoform 3]: Expression is significantly increased in colon and lung cancers.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>Necroptosis; / >>NOD-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>TNF signaling pathway; / >>Salmonella infection
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,