Product details
Background:
STIM1 rabbit pAb
Ucallm_WP17900-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | Stromal Interaction Molecule 1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 75kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal STIM1 |
| Specificity | This antibody detects endogenous levels of STIM1 at Human, Mouse,Rat |
| Gene Name | STIM1 GOK |
| Protein Name | Stromal interaction molecule 1 |
| Other Name | Stromal interaction molecule 1 |
| Species | Human |
| Gene ID | 6786 |
| Uniprot | Q13586, |
| Species.1 | Mouse |
| Gene ID.1 | 20866 |
| Uniprot.1 | P70302, |
| Species.2 | Rat |
| Gene ID.2 | 361618 |
| Uniprot.2 | P84903 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Cytoplasm, cytoskeleton . Sarcoplasmic reticulum . Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). . |
| Tissue Expression | Ubiquitously expressed in various human primary cells and tumor cell lines. |
| Signaling_pathway | Organismal Systems >> Immune system >> Platelet activation;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 . Involved in enamel formation . Activated following interaction with STIMATE, leading to promote STIM1 conformational switch . |
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