Product details
Background:
STIM2 rabbit pAb
Ucallm_WP17930-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | STIM2 |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| MW(Calculated) | 82kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C-ternal STIM2 |
| Specificity | This antibody detects endogenous levels of STIM2 at Human, Mouse |
| Gene Name | STIM2 KIAA1482 |
| Protein Name | Stromal interaction molecule 2 |
| Other Name | Stromal interaction molecule 2 |
| Species | Human |
| Gene ID | 57620 |
| Uniprot | Q9P246, |
| Species.1 | Mouse |
| Gene ID.1 | 116873 |
| Uniprot.1 | P83093 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein . Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. |
| Tissue Expression | Expressed in all tissues and tumor cell lines examined. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. |
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