STING (Phospho Ser366) rabbit pAb
Ucallm_WP10657-50
Price range: $288.00 through $368.00
Product details
Background:
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
Specifications
| Target | STING/TMEM173 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | |
| Modification | Phospho |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human STING (Phospho-Ser366) |
| Sequence | |
| Specificity | This antibody detects endogenous levels of STING (Phospho-Ser366) at Human, Mouse, Rat |
| Gene Name | TMEM173 ERIS MITA STING |
| Protein Name | STING (Phospho-Ser366) |
| Alias | Transmembrane protein 173;Endoplasmic reticulum interferon stimulator;ERIS;Mediator of IRF3 activation;hMITA;Stimulator of interferon genes protein;hSTING; |
| Organism-1 | Human |
| Gene ID-1 | 340061 |
| SwissProt-1 | Q86WV6 |
| Organism-2 | Mouse |
| Gene ID-2 | 72512 |
| SwissProt-2 | Q3TBT3 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited (PubMed:19433799, PubMed:30842659, PubMed:30842653, PubMed:29694889). Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis (PubMed:30842662). . |
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