SVIL Polyclonal Antibody
Ucallm_WP1792-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016],
Specifications
| Size | 50μL/100μL |
| Target | SVIL |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 243kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SVIL Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SVIL |
| Protein Name | Supervillin (Archvillin) (p205/p250) |
| Other Name | |
| Species | Human |
| Gene ID | 6840 |
| Uniprot | O95425, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K4L3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody . Cleavage furrow . Tightly associated with both actin filaments and plasma membranes. |
| Tissue Expression | Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 1 HP (headpiece) domain.,similarity:Contains 5 gelsolin-like repeats.,subcellular location:Tightly associated with both actin filaments and plasma membranes.,subunit:Binds to F-actin.,tissue specificity:Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 2 (archvillin) is muscle specific., |
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