Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Syndecan-4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Syndecan4. AA range:145-194 |
| Specificity | Syndecan-4 Polyclonal Antibody detects endogenous levels of Syndecan-4 protein. |
| Gene Name | SDC4 |
| Protein Name | Syndecan-4 |
| Other Name | SDC4; / Syndecan-4; / SYND4; / Amphiglycan; / Ryudocan core protein |
| Species | Human |
| Gene ID | 6385 |
| Uniprot | P31431, |
| Species.1 | Mouse |
| Gene ID.1 | 20971 |
| Uniprot.1 | O35988, |
| Species.2 | Rat |
| Gene ID.2 | 24771 |
| Uniprot.2 | P34901 |
| Cellular Localization | [Isoform 1]: Membrane; Single-pass type I membrane protein . Secreted . Shedding of the ectodomain produces a soluble form. .; [Isoform 2]: Secreted. |
| Tissue Expression | Expressed in epithelial and fibroblastic cells. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>ECM-receptor interaction; / >>Cell adhesion molecules; / >>Proteoglycans in cancer; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Cell surface proteoglycan that bears heparan sulfate.,Function:Cell surface proteoglycan.,similarity:Belongs to the syndecan proteoglycan family.,subunit:Homodimer. Interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS (By similarity). Interacts with SDCBP.,tissue specificity:Expressed in epithelial and fibroblastic cells., |
