Product details
Background:
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Synemin rabbit pAb
Ucallm_WP6893-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SYNM |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 172kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SYNM |
| Specificity | This antibody detects endogenous levels of SYNM at Human, Mouse |
| Gene Name | SYNM DMN KIAA0353 SYN |
| Protein Name | Synemin (Desmuslin) |
| Other Name | |
| Species | Human |
| Gene ID | 23336 |
| Uniprot | O15061, |
| Species.1 | Mouse |
| Gene ID.1 | 233335 |
| Uniprot.1 | Q70IV5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton. Cell junction, adherens junction. There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere. |
| Tissue Expression | Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. |
| Signaling_pathway | |
| Research Areas | |
| Function | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. |
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