Price range: $268.00 through $328.00
Background:
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
| Size | 50μL/100μL |
| Target | SYNJ2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 165kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SYNJ2 AA range: 145-195 |
| Specificity | This antibody detects endogenous levels of SYNJ2 at Human/Mouse/Rat |
| Gene Name | SYNJ2 KIAA0348 |
| Protein Name | SYNJ2 |
| Other Name | |
| Species | Human |
| Gene ID | 8871 |
| Uniprot | O15056, |
| Species.1 | Mouse |
| Gene ID.1 | 20975 |
| Uniprot.1 | Q9D2G5, |
| Species.2 | Rat |
| Gene ID.2 | 84018 |
| Uniprot.2 | O55207 |
| Cellular Localization | Cytoplasm . Cell membrane . Membrane raft . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Phosphatidylinositol signaling system |
| Function | Alternative products:Additional isoforms seem to exist,Catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,Domain:The C-terminal proline-rich region of isoform 2B2 mediates binding to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.,Function:Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.,similarity:Belongs to the synaptojanin family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAC domain.,similarity:In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family.,subcellular location:Predominantly associated with the particulate fractions.,subunit:Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25., |
