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TAFI Polyclonal Antibody
Ucallm_WP14678-50
Price range: $268.00 through $328.00
Product details
Background:
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Specifications
| Size | 50μL/100μL |
| Target | TAFI |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 48kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CPB2. AA range:321-370 |
| Specificity | TAFI Polyclonal Antibody detects endogenous levels of TAFI protein. |
| Gene Name | CPB2 |
| Protein Name | Carboxypeptidase B2 |
| Other Name | CPB2; / Carboxypeptidase B2; / Carboxypeptidase U; / CPU; / Plasma carboxypeptidase B; / pCPB; / Thrombin-activable fibrinolysis inhibitor; / TAFI |
| Species | Human |
| Gene ID | 1361 |
| Uniprot | Q96IY4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JHH6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Plasma; synthesized in the liver. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades; / >>Pancreatic secretion; / >>Protein digestion and absorption |
| Function | Catalytic activity:Release of C-terminal Arg and Lys from a polypeptide.,cofactor:Binds 1 zinc ion per subunit.,Function:Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Plasma; synthesized in the liver., |
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