TBX21 Polyclonal Antibody
Ucallm_WP3291-50
Price range: $268.00 through $328.00
Product details
Background:
T-box 21(TBX21) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TBX21 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TBX21 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TBX21 TBET TBLYM |
| Protein Name | T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM) |
| Other Name | |
| Species | Human |
| Gene ID | 30009 |
| Uniprot | Q9UL17, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JKD8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | T-cell specific. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Immune disease >> Inflammatory bowel disease |
| Research Areas | >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Inflammatory bowel disease |
| Function | Disease:Genetic variations in TBX21 are associated with susceptibility to aspirin-induced asthma [MIM:208550]. Asthma is defined as a chronic inflammatory lung disease that is characterized by airway hyperreactivity, eosinophil inflammation, and mucus hypersecretion resulting in intermittent airway obstruction.,Disease:Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps [MIM:208550]. Nasal polyps is a chronic inflammatory disease of the paranasal sinus mucosa, leading to the protrusion of edematous polyps into the nasal cavities.,Function:Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:T-cell specific., |
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