TBX3 Polyclonal Antibody
Ucallm_WP14701-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TBX3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 79kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350 |
| Specificity | TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein. |
| Gene Name | TBX3 |
| Protein Name | T-box transcription factor TBX3 |
| Other Name | TBX3; / T-box transcription factor TBX3; / T-box protein 3 |
| Species | Human |
| Gene ID | 6926 |
| Uniprot | O15119, |
| Species.1 | Mouse |
| Gene ID.1 | 21386 |
| Uniprot.1 | P70324, |
| Species.2 | Rat |
| Gene ID.2 | 353305 |
| Uniprot.2 | Q7TST9 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells |
| Research Areas | >>Signaling pathways regulating pluripotency of stem cells |
| Function | Disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,Function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed., |
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