Price range: $268.00 through $328.00
Background:
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TDAG51 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PHLA1. AA range:271-320 |
| Specificity | TDAG51 Polyclonal Antibody detects endogenous levels of TDAG51 protein. |
| Gene Name | PHLDA1 |
| Protein Name | Pleckstrin homology-like domain family A member 1 |
| Other Name | PHLDA1; / PHRIP; / TDAG51; / Pleckstrin homology-like domain family A member 1; / Apoptosis-associated nuclear protein; / Proline- and glutamine-rich protein; / PQ-rich protein; / PQR protein; / Proline- and histidine-rich protein; / T-cell death-associated |
| Species | Human |
| Gene ID | 22822 |
| Uniprot | Q8WV24, |
| Species.1 | Mouse |
| Gene ID.1 | 21664 |
| Uniprot.1 | Q62392, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9QZA1 |
| Cellular Localization | Cytoplasm . Cytoplasmic vesicle . Nucleus, nucleolus . Colocalizes with intracellular vesicles. . |
| Tissue Expression | Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.,induction:Induced by homocysteine and other ER stress-inducing reagents. Induced by phorbolester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.,similarity:Contains 1 PH domain.,subcellular location:Colocalizes with intracellular vesicles.,subunit:Interacts with RPL14, EIF3S7 and PABPC4.,tissue specificity:Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level)., |
