TEL Polyclonal Antibody
Ucallm_WP14729-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008],
Specifications
| Size | 50μL/100μL |
| Target | TEL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ETV6. AA range:371-420 |
| Specificity | TEL Polyclonal Antibody detects endogenous levels of TEL protein. |
| Gene Name | ETV6 |
| Protein Name | Transcription factor ETV6 |
| Other Name | ETV6; / TEL; / TEL1; / Transcription factor ETV6; / ETS translocation variant 6; / ETS-related protein Tel1; / Tel |
| Species | Human |
| Gene ID | 2120 |
| Uniprot | P41212, |
| Species.1 | Mouse |
| Gene ID.1 | 14011 |
| Uniprot.1 | P97360 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer |
| Research Areas | >>Transcriptional misregulation in cancer |
| Function | Disease:A chromosomal aberration involving ETV6 is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5; 12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein.,Disease:A chromosomal aberration involving ETV6 is a cause of acute lymphoblastic leukemia. Translocation t(9; 12)(p13; p13) with PAX5.,Disease:A chromosomal aberration involving ETV6 is a cause of myelodysplastic syndrome (MDS). Translocation t(1; 12)(p36.1; p13) with MDS2.,Disease:A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5; 12)(q33; p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,Disease:A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9; 12)(p24; p13) with JAK2.,Disease:A chromosomal aberration involving ETV6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5; 12)(q31; p13) with ACSL6.,Disease:A chromosomal aberration involving ETV6 may be a cause of myelodysplastic syndrome (MDS) with basophilia. Translocation t(5; 12)(q31; p13) with ACSL6.,Disease:Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12; 22)(p13; q11) with MN1; translocation t(4; 12)(q12; p13) with CHIC2.,Disease:Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12; 21)(p12; q22) and t(12; 21)(p13; q22) with RUNX1/AML1.,Disease:Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.,Function:Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.,PTM:Phosphorylated.,PTM:Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL and HDAC9.,tissue specificity:Ubiquitous., |
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