Teneurin 1 rabbit pAb
Ucallm_WP7526-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TENM1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 300kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Teneurin 1 |
| Specificity | This antibody detects endogenous levels of Teneurin 1 at Human, Mouse |
| Gene Name | ODZ1 TNM1 |
| Protein Name | Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) |
| Other Name | |
| Species | Human |
| Gene ID | 10178 |
| Uniprot | Q9UKZ4, |
| Species.1 | Mouse |
| Gene ID.1 | 23963 |
| Uniprot.1 | Q9WTS4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass membrane protein .; [Ten-1 intracellular domain]: Nucleus . Nucleus speckle . Nucleus matrix . Cytoplasm, cytoskeleton .; [Teneurin C-terminal-associated peptide]: Nucleus . Cytoplasm . Cell membrane . Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). . |
| Tissue Expression | Expressed in fetal brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).; [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).; [Ten-1 intracellular domain]: Induces gene transcription activation. |
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