TGIF2 Polyclonal Antibody
Ucallm_WP1220-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010],
Specifications
| Size | 50μL/100μL |
| Target | TGIF2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 26kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TGIF2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TGIF2 |
| Protein Name | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) |
| Other Name | |
| Species | Human |
| Gene ID | 60436 |
| Uniprot | Q9GZN2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C0Y1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Excluded from nucleoli. |
| Tissue Expression | Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway |
| Research Areas | >>TGF-beta signaling pathway |
| Function | Function:Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.,miscellaneous:TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.,PTM:The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subcellular location:Excluded from nucleoli.,subunit:Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.,tissue specificity:Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate., |
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