Product details
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TGS1 rabbit pAb
Ucallm_WP8607-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TGS1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 94kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TGS1 |
| Specificity | This antibody detects endogenous levels of TGS1 at Human, Mouse,Rat |
| Gene Name | TGS1 HCA137 NCOA6IP PIMT |
| Protein Name | Trimethylguanosine synthase (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) |
| Other Name | |
| Species | Human |
| Gene ID | 96764 |
| Uniprot | Q96RS0, |
| Species.1 | Mouse |
| Gene ID.1 | 116940 |
| Uniprot.1 | Q923W1, |
| Species.2 | Rat |
| Gene ID.2 | 312947 |
| Uniprot.2 | P85107 |
| Cellular Localization | Cytoplasm . Nucleus, Cajal body . Nucleus, nucleolus . A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. . |
| Tissue Expression | Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
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