Price range: $268.00 through $328.00
Background:
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
| Target | Thioredoxin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 12kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | IHC: 100-300;WB 1:500-2000;ELISA 1:10000-20000;IF 1:50-200 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Thioredoxin. at AA range: 52-101 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of Thioredoxin |
| Gene Name | TXN TRDX TRX TRX1 |
| Protein Name | Thioredoxin |
| Alias | Thioredoxin;Trx;ATL-derived factor;ADF;Surface-associated sulphydryl protein;SASP; |
| Organism-1 | Human |
| Gene ID-1 | 7295 |
| SwissProt-1 | P10599 |
| Organism-2 | Mouse |
| Gene ID-2 | 22166 |
| SwissProt-2 | P10639 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). . |
