THNS2 Polyclonal Antibody
Ucallm_WP2828-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],
Specifications
| Size | 50μL/100μL |
| Target | THNS2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 91-140 |
| Specificity | THNS2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | THNSL2 |
| Protein Name | Threonine synthase-like 2 (TSH2) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT) |
| Other Name | |
| Species | Human |
| Gene ID | 55258 |
| Uniprot | Q86YJ6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q80W22, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5M7T9 |
| Cellular Localization | [Isoform SOFAT]: Secreted. Secreted by activated T-cells via a calcineurin-independent pathway. |
| Tissue Expression | Brain,Colon,Ovarian carcinoma,Skin,Tongue, |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Pyridoxal phosphate.,Function:Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.,similarity:Belongs to the serine/threonine dehydratase family., |
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