Product details
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THOC2 rabbit pAb
Ucallm_WP6849-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | THOC2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 175kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human THOC2 |
| Specificity | This antibody detects endogenous levels of THOC2 at Human, Mouse |
| Gene Name | THOC2 CXorf3 |
| Protein Name | THO complex subunit 2 (Tho2) (hTREX120) |
| Other Name | |
| Species | Human |
| Gene ID | 57187 |
| Uniprot | Q8NI27, |
| Species.1 | Mouse |
| Gene ID.1 | 331401 |
| Uniprot.1 | B1AZI6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Nucleus speckle . |
| Tissue Expression | Expressed in the hippocampus and the cerebral cortex. |
| Signaling_pathway | Genetic Information Processing >> Translation >> Nucleocytoplasmic transport |
| Research Areas | |
| Function | Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. |
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