Thrombospondin 4 Polyclonal Antibody
Ucallm_WP14770-50
Price range: $268.00 through $328.00
Product details
Background:
thrombospondin 4(THBS4) Homo sapiens The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Specifications
| Size | 50μL/100μL |
| Target | Thrombospondin 4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 106kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human THBS4. AA range:561-610 |
| Specificity | Thrombospondin 4 Polyclonal Antibody detects endogenous levels of Thrombospondin 4 protein. |
| Gene Name | THBS4 |
| Protein Name | Thrombospondin-4 |
| Other Name | THBS4; / TSP4; / Thrombospondin-4 |
| Species | Human |
| Gene ID | 7060 |
| Uniprot | P35443, |
| Species.1 | Mouse |
| Gene ID.1 | 21828 |
| Uniprot.1 | Q9Z1T2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | Heart,PNS,Synovium, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>Phagosome; / >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>ECM-receptor interaction; / >>Malaria; / >>Human papillomavirus infection |
| Function | Function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 4 EGF-like domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homopentamer; disulfide-linked., |
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