Thymidine Kinase Polyclonal Antibody
Ucallm_WP14772-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:ATP + thymidine = ADP + thymidine 5′-phosphate., miscellaneous:Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells., PTM:Phosphorylated on Ser-13 in mitosis., similarity:Belongs to the thymidine kinase family.,
Specifications
| Size | 50μL/100μL |
| Target | Thymidine Kinase |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TK. AA range:1-50 |
| Specificity | Thymidine Kinase Polyclonal Antibody detects endogenous levels of Thymidine Kinase protein. |
| Gene Name | TK1 |
| Protein Name | Thymidine kinase cytosolic |
| Other Name | TK1; / Thymidine kinase; / cytosolic |
| Species | Human |
| Gene ID | 7083 |
| Uniprot | P04183, |
| Species.1 | Mouse |
| Gene ID.1 | 21877 |
| Uniprot.1 | P04184, |
| Species.2 | Rat |
| Gene ID.2 | 24834 |
| Uniprot.2 | P27158 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Epithelium,Lymph,Skin,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Pyrimidine metabolism; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Nucleotide metabolism |
| Function | Catalytic activity:ATP + thymidine = ADP + thymidine 5'-phosphate.,miscellaneous:Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.,PTM:Phosphorylated on Ser-13 in mitosis.,similarity:Belongs to the thymidine kinase family., |
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