Thyroglobulin [PT0653] mouse mAb
Ucallm_WM1627-50
Price range: $268.00 through $328.00
Product details
Background:
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009],
Specifications
| Size | 50μL/100μL |
| Target | Thyroglobulin |
| Reactivity | Human |
| Applications | IHC, ELISA |
| MW(Calculated) | 305kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM0653 |
| Immunogen | Synthesized peptide derived from human Thyroglobulin AA range: 2700-2768 |
| Specificity | The antibody can specifically recognize human Thyroglobulin protein. |
| Gene Name | TG |
| Protein Name | Thyroglobulin |
| Other Name | Thyroglobulin; / Tg |
| Species | Human |
| Gene ID | 7038 |
| Uniprot | P01266 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Specifically expressed in the thyroid gland. |
| Signaling_pathway | Human Diseases >> Immune disease >> Autoimmune thyroid disease |
| Research Areas | >>Thyroid hormone synthesis; / >>Autoimmune thyroid disease |
| Function | Disease:Defects in TG are a cause of some forms of goiter [MIM:188450]. Goiter is an enlargement of the thyroid gland. This is sometimes linked to hypothyroidism.,Disease:Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.,Function:Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).,online information:Thyroglobulin entry,PTM:Sulfated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,similarity:Contains 11 thyroglobulin type-1 domains.,subunit:Homodimer.,tissue specificity:Thyroid gland specific., |
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