Price range: $268.00 through $328.00
Background:
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
| Size | 50μL/100μL |
| Target | TIEG-1/2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KLF10/11. AA range:391-440 |
| Specificity | TIEG-1/2 Polyclonal Antibody detects endogenous levels of TIEG-1/2 protein. |
| Gene Name | KLF10/11 |
| Protein Name | Krueppel-like factor 10/11 |
| Other Name | KLF10; / TIEG; / TIEG1; / Krueppel-like factor 10; / EGR-alpha; / Transforming growth factor-beta-inducible early growth response protein 1; / TGFB-inducible early growth response protein 1; / TIEG-1; / KLF11; / FKLF; / TIEG2; / Krueppel-like factor 11; / Transfor |
| Species | Human |
| Gene ID | 7071;8462 |
| Uniprot | Q13118;O14901, |
| Species.1 | Mouse |
| Gene ID.1 | 21847;194655, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 81813 |
| Uniprot.2 | O08876 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Epithelium,Eye,Placenta, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.,induction:By TGF-beta.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers., |
