SKU: WP14780 Categories: ,

TIMAP Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14780-100
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Product details

Background:

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],

Specifications

Size50μL/100μL
TargetTIMAP
ReactivityHuman, Mouse
ApplicationsWB, IHC
MW(Calculated)
MW(Observed)64kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413
SpecificityTIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein.
Gene NamePPP1R16B
Protein NameProtein phosphatase 1 regulatory inhibitor subunit 16B
Other NamePPP1R16B; / ANKRD4; / KIAA0823; / Protein phosphatase 1 regulatory inhibitor subunit 16B; / Ankyrin repeat domain-containing protein 4; / CAAX box protein TIMAP; / TGF-beta-inhibited membrane-associated protein; / hTIMAP
SpeciesHuman
Gene ID26051
UniprotQ96T49,
Species.1Mouse
Gene ID.1228852
Uniprot.1Q8VHQ3
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane . Cell membrane; Lipid-anchor . Nucleus . Cell projection . Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). .
Tissue ExpressionBrain,
Signaling_pathway
Research Areas
FunctionFunction:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.,
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