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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TLX1 Polyclonal Antibody
SKU: WP1820 Categories: ,

TLX1 Polyclonal Antibody

Ucallm_WP1820-50

Price range: $268.00 through $328.00

SKU: WP1820-100
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Product details

Background:

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010],

Specifications

Size50μL/100μL
TargetTLX1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)36kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityTLX1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameTLX1 HOX11 TCL3
Protein NameT-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Other Name
SpeciesHuman
Gene ID3195
UniprotP31314,
Species.1Mouse
Gene ID.1
Uniprot.1P43345
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionPooled,
Signaling_pathwayHuman Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Research Areas>>Transcriptional misregulation in cancer
FunctionDisease:A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10; 14)(q24; q11) with TCRD.,Function:Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.,miscellaneous:TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.,similarity:Contains 1 homeobox DNA-binding domain.,
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