TM4SF1 Polyclonal Antibody
Ucallm_WP14798-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TM4SF1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50 |
| Specificity | TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein. |
| Gene Name | TM4SF1 |
| Protein Name | Transmembrane 4 L6 family member 1 |
| Other Name | TM4SF1; / M3S1; / TAAL6; / Transmembrane 4 L6 family member 1; / Membrane component chromosome 3 surface marker 1; / Tumor-associated antigen L6 |
| Species | Human |
| Gene ID | 4071 |
| Uniprot | P30408, |
| Species.1 | Mouse |
| Gene ID.1 | 17112 |
| Uniprot.1 | Q64302 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). . |
| Tissue Expression | Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. |
| Signaling_pathway | |
| Research Areas | |
| Function | similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular., |
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