Product details
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TMEM35 rabbit pAb
Ucallm_WP8266-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TMEM35A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 18kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMEM35 |
| Specificity | This antibody detects endogenous levels of TMEM35 at Human, Mouse,Rat |
| Gene Name | TMEM35 |
| Protein Name | Transmembrane protein 35 |
| Other Name | |
| Species | Human |
| Gene ID | 59353 |
| Uniprot | Q53FP2, |
| Species.1 | Mouse |
| Gene ID.1 | 67564 |
| Uniprot.1 | Q9D328, |
| Species.2 | Rat |
| Gene ID.2 | 308134 |
| Uniprot.2 | Q6JAM9 |
| Cellular Localization | Peroxisome membrane; Multi-pass membrane protein . Cytoplasmic vesicle . Endoplasmic reticulum membrane; Multi-pass membrane protein . Shedding may lead to a soluble peptide. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain . Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors . Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly . Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form . |
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