TNF-IP 8 Polyclonal Antibody
Ucallm_WP14808-50
Price range: $268.00 through $328.00
Product details
Background:
developmental stage:Expressed at high levels in the fetal liver, lung and kidney., function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation., induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB., similarity:Belongs to the TNFAIP8 family., tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.,
Specifications
| Size | 50μL/100μL |
| Target | TNF-IP 8 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TFIP8. AA range:31-80 |
| Specificity | TNF-IP 8 Polyclonal Antibody detects endogenous levels of TNF-IP 8 protein. |
| Gene Name | TNFAIP8 |
| Protein Name | Tumor necrosis factor alpha-induced protein 8 |
| Other Name | TNFAIP8; / Tumor necrosis factor alpha-induced protein 8; / TNF alpha-induced protein 8; / Head and neck tumor and metastasis-related protein; / MDC-3.13; / NF-kappa-B-inducible DED-containing protein; / NDED; / SCC-S2; / TNF-induced protein GG2-1 |
| Species | Human |
| Gene ID | 25816 |
| Uniprot | O95379, |
| Species.1 | Mouse |
| Gene ID.1 | 106869 |
| Uniprot.1 | Q921Z5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expressed at high levels in the fetal liver, lung and kidney.,Function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.,induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.,similarity:Belongs to the TNFAIP8 family.,tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle., |
Please login to post questions
Related products
