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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TNNC1 rabbit pAb
SKU: WP4029 Categories: ,

TNNC1 rabbit pAb

Ucallm_WP4029-50

Price range: $268.00 through $328.00

SKU: WP4029-100
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Product details

Background:

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008],

Specifications

Size50μL/100μL
TargetTNNC1
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)18kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human TNNC1 AA range: 57-107
SpecificityThis antibody detects endogenous levels of TNNC1 at Human/Mouse
Gene NameTNNC1 TNNC
Protein NameTNNC1
Other Name
SpeciesHuman
Gene ID7134
UniprotP63316,
Species.1Mouse
Gene ID.121924
Uniprot.1P19123
Species.2
Gene ID.2
Uniprot.2
Cellular Localizationnucleoplasm,mitochondrion,cytosol,troponin complex,actin cytoskeleton,contractile fiber,
Tissue Expression
Signaling_pathwayOrganismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas>>Calcium signaling pathway; / >>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Hypertrophic cardiomyopathy; / >>Dilated cardiomyopathy
FunctionDisease:Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,Function:Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.,miscellaneous:Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.,similarity:Belongs to the troponin C family.,similarity:Contains 4 EF-hand domains.,
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