Price range: $268.00 through $328.00
Background:
function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on ‘Ser-46’ and subsequent apoptosis., induction:By adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way. At lower levels by ultraviolet irradiation., subcellular location:Concentrated in PML/POD/ND10 nuclear bodies., subunit:Interacts with TP53 and HIPK2., tissue specificity:Ubiquitously expressed.,
| Size | 50μL/100μL |
| Target | TP53INP1 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 27kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220 |
| Specificity | TP53INP1 Polyclonal Antibody detects endogenous levels of TP53INP1 protein. |
| Gene Name | TP53INP1 |
| Protein Name | Tumor protein p53-inducible nuclear protein 1 |
| Other Name | TP53INP1; / P53DINP1; / SIP; / Tumor protein p53-inducible nuclear protein 1; / Stress-induced protein; / p53-dependent damage-inducible nuclear protein 1; / p53DINP1 |
| Species | Human |
| Gene ID | 94241 |
| Uniprot | Q96A56, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QXE4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.,induction:By adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way. At lower levels by ultraviolet irradiation.,subcellular location:Concentrated in PML/POD/ND10 nuclear bodies.,subunit:Interacts with TP53 and HIPK2.,tissue specificity:Ubiquitously expressed., |
