TRAF7 Polyclonal Antibody
Ucallm_WP1114-50
Price range: $268.00 through $328.00
Product details
Background:
TNF receptor associated factor 7(TRAF7) Homo sapiens Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004],
Specifications
| Size | 50μL/100μL |
| Target | TRAF7 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 73kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TRAF7 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TRAF7 RFWD1 RNF119 |
| Protein Name | E3 ubiquitin-protein ligase TRAF7 (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) |
| Other Name | |
| Species | Human |
| Gene ID | 84231 |
| Uniprot | Q6Q0C0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q922B6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic vesicle . Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. |
| Tissue Expression | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta., |
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