U-Blot® Transglutaminase 2 Rabbit mAb
Ucallm_WR5024-50
Price range: $268.00 through $328.00
Product details
Background:Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Transglutaminase 2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 77kD |
| MW(Observed) | 77kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1256R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TGM2 |
| Protein Name | Protein-glutamine gamma-glutamyltransferase 2 |
| Other Name | TGM2; / Protein-glutamine gamma-glutamyltransferase 2; / Tissue transglutaminase; / Transglutaminase C; / TG; / C; / TGC; / TGase C; / Transglutaminase H; / TGase H; / Transglutaminase-2; / TGase-2 |
| Species | Human |
| Gene ID | 7052 |
| Uniprot | P21980, |
| Species.1 | Mouse |
| Gene ID.1 | 21817 |
| Uniprot.1 | P21981 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . Nucleus . Chromosome . Secreted, extracellular space, extracellular matrix . Cell membrane . Mitochondrion . Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). .; [Isoform 2]: Cytoplasm, perinuclear region . |
| Tissue Expression | Brain,Colon adenocarcinoma,Endothelial cell,Kidney,Liver,Lymph node,Ovarian carcino |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Huntington disease |
| Research Areas | >>Huntington disease |
| Function | Catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,Disease:Defects in TGM2 are involved in early-onset diabetes type 2.,Function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer., |
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