Price range: $268.00 through $328.00
Background:
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011],
| Size | 50μL/100μL |
| Target | TRH-R1 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TRHR. AA range:195-244 |
| Specificity | TRH-R1 Polyclonal Antibody detects endogenous levels of TRH-R1 protein. |
| Gene Name | TRHR |
| Protein Name | Thyrotropin-releasing hormone receptor |
| Other Name | TRHR; / Thyrotropin-releasing hormone receptor; / TRH-R; / Thyroliberin receptor |
| Species | Human |
| Gene ID | 7201 |
| Uniprot | P34981, |
| Species.1 | Mouse |
| Gene ID.1 | 22045 |
| Uniprot.1 | P21761, |
| Species.2 | Rat |
| Gene ID.2 | 25570 |
| Uniprot.2 | Q01717 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Pituitary,Placenta, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family., |
