TRIM2 rabbit pAb
Ucallm_WP3845-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014],
Specifications
| Size | 50μL/100μL |
| Target | TRIM2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 82kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM2 AA range: 162-212 |
| Specificity | This antibody detects endogenous levels of TRIM2 at Human/Mouse/Rat |
| Gene Name | TRIM2 KIAA0517 RNF86 |
| Protein Name | TRIM2 |
| Other Name | |
| Species | Human |
| Gene ID | 23321 |
| Uniprot | Q9C040, |
| Species.1 | Mouse |
| Gene ID.1 | 80890 |
| Uniprot.1 | Q9ESN6, |
| Species.2 | Rat |
| Gene ID.2 | 361970 |
| Uniprot.2 | D3ZQG6 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.,Function:May contribute to the alteration of neural cellular mechanisms.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 filamin repeat.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 6 NHL repeats.,subunit:Interacts with myosin V., |
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