TRIM9 rabbit pAb
Ucallm_WP6434-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TRIM9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 78kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM9 |
| Specificity | This antibody detects endogenous levels of TRIM9 at Human, Mouse,Rat |
| Gene Name | TRIM9 KIAA0282 RNF91 |
| Protein Name | E3 ubiquitin-protein ligase TRIM9 (RING finger protein 91) (Tripartite motif-containing protein 9) |
| Other Name | |
| Species | Human |
| Gene ID | 114088 |
| Uniprot | Q9C026, |
| Species.1 | Mouse |
| Gene ID.1 | 94090 |
| Uniprot.1 | Q8C7M3, |
| Species.2 | Rat |
| Gene ID.2 | 155812 |
| Uniprot.2 | Q91ZY8 |
| Cellular Localization | Cytoplasm . Cell projection, dendrite . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse . Cytoplasm, cytoskeleton . Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). . |
| Tissue Expression | Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. |
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