Name: Trk C Polyclonal Antibody
SKU: WP15245
Price: 268 USD
Availability: InStock

Trk C Polyclonal Antibody

Ucallm_WP15245-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15245-100

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Product details

Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

Specifications

Size	50μL/100μL
Target	Trk C
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	95kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human NTRK3. AA range:281-330
Specificity	Trk C Polyclonal Antibody detects endogenous levels of Trk C protein.
Gene Name	NTRK3
Protein Name	NT-3 growth factor receptor
Other Name	NTRK3; / TRKC; / NT-3 growth factor receptor; / GP145-TrkC; / Trk-C; / Neurotrophic tyrosine kinase receptor type 3; / TrkC tyrosine kinase
Species	Human
Gene ID	4916
Uniprot	Q16288,
Species.1	Mouse
Gene ID.1	18213
Uniprot.1	Q6VNS1,
Species.2	Rat
Gene ID.2	29613
Uniprot.2	Q03351
Cellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Expression	Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas	>>Calcium signaling pathway; / >>Neurotrophin signaling pathway; / >>Central carbon metabolism in cancer
Function	Alternative products:Additional isoforms seem to exist,Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.,