Name: TRPC3 Polyclonal Antibody
SKU: WP15535
Price: 268 USD
Availability: InStock

TRPC3 Polyclonal Antibody

Ucallm_WP15535-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15535-100

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Product details

Background:

transient receptor potential cation channel subfamily C member 3(TRPC3) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size	50μL/100μL
Target	TRPC3
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	97kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human TRPC3. AA range:411-460
Specificity	TRPC3 Polyclonal Antibody detects endogenous levels of TRPC3 protein.
Gene Name	TRPC3
Protein Name	Short transient receptor potential channel 3
Other Name	TRPC3; / TRP3; / Short transient receptor potential channel 3; / TrpC3; / Transient receptor protein 3; / TRP-3; / hTrp-3; / hTrp3
Species	Human
Gene ID	7222
Uniprot	Q13507,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9QZC1,
Species.2	Rat
Gene ID.2
Uniprot.2	Q9JMI9
Cellular Localization	Membrane; Multi-pass membrane protein.
Tissue Expression	Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Signaling_pathway	Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas	>>Axon guidance; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases
Function	Function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 5 ANK repeats.,subunit:Interacts with TRPC1. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.,

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TRPC3 Polyclonal Antibody

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TRPC3 Polyclonal Antibody

Product details

Specifications

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