TRYG1 Polyclonal Antibody
Ucallm_WP2795-50
Price range: $268.00 through $328.00
Product details
Background:
tryptase gamma 1(TPSG1) Homo sapiens Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes – alpha I, beta I, beta II and gamma I – have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathog
Specifications
| Size | 50μL/100μL |
| Target | TRYG1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 110-190 |
| Specificity | TRYG1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TPSG1 PRSS31 TMT |
| Protein Name | Tryptase gamma (Serine protease 31) (Transmembrane tryptase) [Cleaved into: Tryptase gamma light chain; Tryptase gamma heavy chain] |
| Other Name | |
| Species | Human |
| Gene ID | 25823 |
| Uniprot | Q9NRR2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QUL7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass membrane protein . |
| Tissue Expression | Expressed in many tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | polymorphism:There are two alleles; gamma-I and gamma-II which differ by 5 residues.,similarity:Belongs to the peptidase S1 family. Tryptase subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in many tissues., |
Please login to post questions
Related products
