Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human TSEPA
Specificity
This antibody detects endogenous levels of TSEPA at Human, Mouse
Gene Name
THEMIS C6orf190 C6orf207
Protein Name
Protein THEMIS (Thymocyte-expressed molecule involved in selection)
Other Name
Species
Human
Gene ID
387357
Uniprot
Q8N1K5,
Species.1
Mouse
Gene ID.1
210757
Uniprot.1
Q8BGW0
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Cytoplasm . Nucleus .
Tissue Expression
Signaling_pathway
Research Areas
Function
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.