Price range: $268.00 through $328.00
Background:This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
| Target | TSFM |
| Reactivity | Human |
| Applications | WB, IF, ICC |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:1000-5000; ICC/IF 1:100-300 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | PT0800R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Sequence | |
| Specificity | Endogenous |
| Gene Name | TSFM |
| Protein Name | Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) |
| Other Name | TSFM; / Elongation factor Ts, mitochondrial; / EF-Ts; / EF-TsMt |
| Species | Human |
| Gene ID-1 | 10102 |
| Uniprot | P43897, |
| Species.1 | Mouse |
| Gene ID-2 | 66399 |
| Uniprot.1 | Q9CZR8, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | Q9QYU2 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010] |
| Cellular Localization | Mitochondrion. |
| Tissue Expression | Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {ECO:0000255|HAMAP-Rule:MF_03135, ECO:0000269|PubMed:27677415}. |
| RRID |
