TSG-6 Polyclonal Antibody
Ucallm_WP14880-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010],
Specifications
| Size | 50μL/100μL |
| Target | TSG-6 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 31kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TSG6. AA range:21-70 |
| Specificity | TSG-6 Polyclonal Antibody detects endogenous levels of TSG-6 protein. |
| Gene Name | TNFAIP6 |
| Protein Name | Tumor necrosis factor-inducible gene 6 protein |
| Other Name | TNFAIP6; / TSG6; / Tumor necrosis factor-inducible gene 6 protein; / Hyaluronate-binding protein; / TNF-stimulated gene 6 protein; / TSG-6; / Tumor necrosis factor alpha-induced protein 6; / TNF alpha-induced protein 6 |
| Species | Human |
| Gene ID | 7130 |
| Uniprot | P98066, |
| Species.1 | Mouse |
| Gene ID.1 | 21930 |
| Uniprot.1 | O08859 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (PubMed:16771708). Found in the synovial fluid of patients with rheumatoid arthritis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.,induction:By TNF.,similarity:Contains 1 CUB domain.,similarity:Contains 1 Link domain.,subunit:Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.,tissue specificity:Found in the synovial fluid of patients with rheumatoid arthritis., |
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