TudorSN Polyclonal Antibody
Ucallm_WP15178-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],
Specifications
| Size | 50μL/100μL |
| Target | TudorSN |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 101kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human TudorSN. |
| Specificity | TudorSN Polyclonal Antibody detects endogenous levels of TudorSN protein. |
| Gene Name | SND1 |
| Protein Name | Staphylococcal nuclease domain-containing protein 1 |
| Other Name | SND1; / TDRD11; / Staphylococcal nuclease domain-containing protein 1; / 100 kDa coactivator; / EBNA2 coactivator p100; / Tudor domain-containing protein 11; / p100 co-activator |
| Species | Human |
| Gene ID | 27044 |
| Uniprot | Q7KZF4, |
| Species.1 | Mouse |
| Gene ID.1 | 56463 |
| Uniprot.1 | Q78PY7, |
| Species.2 | Rat |
| Gene ID.2 | 64635 |
| Uniprot.2 | Q66X93 |
| Cellular Localization | Cytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | >>Viral carcinogenesis |
| Function | Function:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence Caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed., |
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