Product details
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TXNIP rabbit pAb
Ucallm_WP17927-50
Price range: $268.00 through $328.00
Specifications
| Target | TXNIP |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 43kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal TXNIP |
| Sequence | |
| Specificity | This antibody detects endogenous levels of TXNIP at Human, Mouse,Rat |
| Gene Name | TXNIP VDUP1 |
| Protein Name | Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) |
| Other Name | Thioredoxin-interacting protein; / Thioredoxin-binding protein 2; / Vitamin D3 up-regulated protein 1 |
| Species | Human |
| Gene ID-1 | 10628 |
| Uniprot | Q9H3M7, |
| Species.1 | Mouse |
| Gene ID-2 | 56338 |
| Uniprot.1 | Q8BG60, |
| Species.2 | Rat |
| Gene ID-3 | 117514 |
| Uniprot.2 | Q5M7W1 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| RRID |
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