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Background:
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008],
| Target | TYDP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 40kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TYDP2 AA range: 261-311 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of TYDP2 at Human/Mouse/Rat |
| Gene Name | TDP2 EAP2 TTRAP AD-022 |
| Protein Name | TYDP2 |
| Other Name | |
| Species | Human |
| Gene ID-1 | 51567 |
| Uniprot | O95551, |
| Species.1 | Mouse |
| Gene ID-2 | 56196 |
| Uniprot.1 | Q9JJX7, |
| Species.2 | Rat |
| Gene ID-3 | 498749 |
| Uniprot.2 | Q3T1H5 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Nucleus . Nucleus, PML body . Nucleus, nucleolus . Cytoplasm. Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. .; Cytoplasm . (Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. . |
| Tissue Expression | Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003). |
| Signaling_pathway | |
| Research Areas | |
| Function | |
| RRID |
