Tyro3 Monoclonal Antibody
Ucallm_WM0458-50
Price range: $268.00 through $328.00
Product details
Background:
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010],
Specifications
| Size | 50μL/100μL |
| Target | Tyro3 |
| Reactivity | Human |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 97kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 17C11 |
| Immunogen | Purified recombinant fragment of Tyro3 expressed in E. Coli. |
| Specificity | Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein. |
| Gene Name | TYRO3 |
| Protein Name | Tyrosine-protein kinase receptor TYRO3 |
| Other Name | TYRO3; / BYK; / DTK; / RSE; / SKY; / Tyrosine-protein kinase receptor TYRO3; / Tyrosine-protein kinase DTK; / Tyrosine-protein kinase RSE; / Tyrosine-protein kinase SKY; / Tyrosine-protein kinase byk |
| Species | Human |
| Gene ID | 7301 |
| Uniprot | Q06418, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P55144 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Abundant in the brain and lower levels in other tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:May be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer and homodimer. Interacts with GAS6.,tissue specificity:Abundant in the brain and lower levels in other tissues., |
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