U-Blot® β-Hydroxybutyryllysine MultiPTM Rabbit Monoclonal Antibody mix
Price range: $550.00 through $1,400.00
Product details
Background:Histones are subject to a variety of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
Specifications
| Target | β-Hydroxybutyryllysine |
| Reactivity | Species Independent |
| Application | WB、DB |
| MW(Calculated) | Multiple |
| MW(Observed) | Multiple |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Lysine β-Hydroxybutyrylation |
| Modification Site | Lys（K） |
| Recommended dilution ratio | WB 1:1000、DB 1:1000 |
| Composition | PBS, 40% Glycerol, 0.05% BSA, 0.02% sodium azide |
| Purification process | |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles |
| Stability | Stable for 12 months from date of receipt / reconstitution. |
| Concentration | 1 mg/ml |
| Clonal | Recombinant monoclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide |
| Gene Name | |
| Protein Name | |
| Alternative name | Kbhb |
| Organism-1 | |
| Gene ID | |
| SwissProt-1 | |
| Cellular Localization |
Please login to post questions
Related products
