Name: U-Blot® Actin, Muscle Specific Rabbit mAb (Ready to Use)
SKU: WR8114
Price: 168 USD
Availability: InStock

Product details

Background：
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008],

Specifications

Size	6mL
Target	Actin_Muscle Specific
Reactivity	Human, Mouse, Rat, Bovine, Pig, Chicken
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Purification	Recombinant Expression and Affinity purified
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	RM0284R
Immunogen	Synthesized peptide derived from human Actin, Muscle Specific AA range:1-100
Specificity	This antibody detects endogenous levels of Actin, Muscle Specific
Gene Name	ACTA1; ACTA2; ACTC1; ACTG2
Protein Name	α-Skeletal Muscle Actin (α-SA); α-Cardiac Muscle Actin (α-CA); α-Smooth Muscle Actin (α-SMA); γ-Smooth Muscle Actin (γ-SMA)
Other Name
Species	Human
Gene ID	58;59;70;72
Uniprot	P68032;P68133;P63267;P62736
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic
Tissue Expression	Muscle,Tongue,
Signaling_pathway	Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Research Areas	>>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Hypertrophic cardiomyopathy; / >>Dilated cardiomyopathy
Function	Disease:Defects in ACTC1 are the cause of cardiomyopathy dilated type 1R (CMD1R) [MIM:102540]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,Disease:Defects in ACTC1 are the cause of cardiomyopathy familial hypertrophic type 11 (CMH11) [MIM:612098]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.,

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U-Blot® Actin, Muscle Specific Rabbit mAb (Ready to Use)

Product details

Specifications

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U-Blot® Actin, Muscle Specific Rabbit mAb (Ready to Use)

Product details

Specifications

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