SKU: WR5960 Categories: ,

U-Blot® ALDH1A2 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5960-50
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Product details

Background:
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid , the active derivative of vitamin A (retinol) , is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1 , concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq , May 2011] ,

Specifications

Size50μL/100μL
TargetALDH1A2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)57kD
MW(Observed)57kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1908R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameALDH1A2
Protein NameRetinal dehydrogenase 2
Other NameALDH1A2; / RALDH2; / Retinal dehydrogenase 2; / RALDH 2; / RalDH2; / Aldehyde dehydrogenase family 1 member A2; / Retinaldehyde-specific dehydrogenase type 2; / RALDH; / II
SpeciesHuman
Gene ID8854
UniprotO94788,
Species.1Mouse
Gene ID.119378
Uniprot.1Q62148,
Species.2Rat
Gene ID.2116676
Uniprot.2Q63639
Cellular LocalizationCytoplasm.
Tissue ExpressionTestis,Uterus,
Signaling_pathway
Research Areas>>Retinol metabolism; / >>Metabolic pathways
FunctionCatalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,Function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,
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