U-Blot® Bcl-10 Rabbit mAb
Ucallm_WR5710-50
Price range: $268.00 through $328.00
Product details
Background:This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Specifications
| Target | Bcl-10 |
| Reactivity | Human |
| Applications | WB,IHC,IF,IP,ELISA |
| MW(Calculated) | 26kD |
| MW(Observed) | 32kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Modified site | |
| Recommended Dilution Ratio | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Composition | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification Process | Protein A |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | PT1504R |
| Immunogen | |
| Sequence | |
| Specificity | Endogenous |
| Gene Name | BCL10 |
| Protein Name | B-cell lymphoma/leukemia 10 |
| Alias | BCL10;CIPER;CLAP;B-cell lymphoma/leukemia 10;B-cell CLL/lymphoma 10;Bcl-10;CARD-containing molecule enhancing NF-kappa-B;CARD-like apoptotic protein;hCLAP;CED-3/ICH-1 prodomain homologous E10-like regulator;CIPER;Cellular homolog |
| Organism-1 | Human |
| Gene ID-1 | 8915 |
| SwissProt-1 | O95999 |
| Organism-2 | Mouse |
| GeneID-2 | 12042.0 |
| SwissProt-2 | Q9Z0H7 |
| Organism-3 | Rat |
| GeneID-3 | 83477.0 |
| SwissProt-3 | Q9QYN5 |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Cellular Localization | Cytoplasm, perinuclear region . Membrane raft . Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. . |
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